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Flashbacks (featuring special guest stars Steven Culp, Jesse Metcalfe and Roger Bart) take us back to key moments in time for Bree, Lynette, Susan and Gabrielle and how they connect to the present. After hearing Betty’s message on her cellphone about Matthew being a murderer Bree realizes she needs to escape from the psychiatric hospital and help Danielle, who has run away with him. When he sees Mike buying an engagement ring, Karl buys Susan a house. Lynette finds out that Tom has an illegitimate daughter from before they were married. Gabrielle discovers a shocking secret her husband has been keeping from her.

Flashbacks (featuring special guest star Steven Culp) take us back to moving-in day on Wisteria Lane for Bree, Lynette, Susan and Gabrielle and how Mary Alice brought them all together. Also, in other flashbacks we are taken back to the day Melanie Foster was murdered. Back in the present, Bree gets some frightening news. Susan moves into a trailer after her house was burnt down. Lynette and the kids are staying at a hotel. After seeing a report on the news, Gabrielle believes Carlos died. Paul begs Zach to get him a good lawyer via Noah.

Reaching the end of her rope, Bree checks herself into the Fairview psychiatric hospital. Lynette suspects that Tom is cheating on her, so she follows him to Atlantic City. Susan must start over. Felicia Tilman has more in store for Paul Young, resulting in their war reaching its final battle. Gaby and Carlos get Xiao-Mei pregnant.